Jie Zheng
Food and Drug Administration, USA
Title: Discovery of Naturally-occurring broad-spectrum cyclic antibiotics from Paenibacillus alvei
Biography
Biography: Jie Zheng
Abstract
The rise of antimicrobial resistance necessitates the discovery and/or production of novel antibiotics. Naturally-occurring
gram-positive bacteria identifi ed as Paenibacillus alvei were isolated from plants native to the Virginia Eastern Shore
tomato growing region and used as biocontrol strain against Salmonella on tomato plant. Th e strains were also showed broadspectrum
antimicrobial activity against gram-negative and gram-positive foodborne pathogens. A novel class of broadspectrum
antibiotic compound was identifi ed with genome mining and multiple-stage tandem mass spectrometry.