Majid Avijgan
Isfahan University o Medical Sciences, Iran
Title: Synergistic activity between echinophora platyloba DC ethanolic extract and azole drugs againstclinical isolates of candida albicans from women suffering chronic recurrent vaginitis
Biography
Biography: Majid Avijgan
Abstract
Objective: Candida albicans is one of the main causes of vaginitis, especially in women with recurrent episodes. Th e appearance of
drug resistant C. albicans and adverse eff ects of chemical agents have raised interest in Echinophora platyloba as one of four native
species in Traditional Persian-Iranian medicine.
Materials & Methods: Th is study evaluates the antifungal activity of ethanolic extract from dried aerial parts of E. platyloba against
27 clinical isolates of C. albicans from women suff ering chronic recurrent vaginitis by micro-broth dilution assay. Th e synergistic
eff ect of azoledrugs and E. platyloba ethanolic extract were also determined by disc diff usion method aft er determining the MIC90.
Results: Th e results of this study showed a potent synergistic eff ect of E. platyloba ethanolic extract and itraconazole (P<0.01) and
fl uconazole (P<0.001) but an antagonistic eff ect between E. platyloba ethanolic extract and clotrimazole and miconazole against
clinicalisolates of C. albicans.
Conclusions: Th ese results must be confi rmed by clinical application and by further clinical studies.